Leptin 2: Why Diet and Exercise Aren’t Enough
Dr. Hackett
4/16/20251 min read
Leptin 2: Why Diet and Exercise Aren’t Enough
Let’s cut to the truth no one wants to admit: for most people, diet and exercise alone don’t work. Not because they’re lazy, unmotivated, or weak-willed—but because their biology has been hijacked upstream. And that hijack begins with leptin.
Leptin isn’t just another hormone—it’s the ultimate metabolic regulator. When it’s functioning properly, the body operates like a high-performance machine. But when resistance sets in, the entire engine sputters. At that point, obsessing over calories or macros becomes like polishing the dashboard of a car with no fuel. It misses the point entirely.
In this second layer of understanding, it becomes clear that leptin doesn’t just control energy balance—it determines whether the body even listens to your willpower. Leptin-resistant individuals can’t properly burn fat, because the muscle system is no longer receiving accurate signals. Even worse, the brain keeps receiving "starvation mode" alerts despite abundant body fat. The result? Increased hunger, lower energy, poor sleep, and dysfunctional thyroid output.
And here’s the kicker: exercise can actually make things worse in a leptin-resistant state. Training hard without first restoring proper energy signaling just adds more stress to an already misfiring system—elevating cortisol, tanking recovery, and worsening the hormonal chaos.
This is why people plateau. This is why they “do everything right” and still gain weight. It’s not a moral failure—it’s a metabolic one.
What most miss is that leptin is wired into ancient environmental signals. It’s set and reset by circadian light, seasonal eating, cold exposure, and sleep. Not treadmills. Not keto. Not HIIT bootcamps. Not willpower.
To fix leptin, you have to think upstream. That means:
Eating your biggest meal in the morning, not at night
Getting sunlight in your eyes shortly after waking
Sleeping in total darkness
Avoiding snacking—especially after sundown
Building a solar callus on your skin
Using cold as a reset tool
Eliminating artificial light, blue screens, and EMF overload
Syncing your daily rhythm to nature, not to tech
This isn’t about dieting harder. It’s about reclaiming the ancient signals your biology evolved to expect.
Leptin is what allows your body to hear the plan. Without it, even the best strategy will fall flat.
If you’ve been spinning your wheels, it’s time to stop asking, “What more can I do?” and start asking, “What does my body need to hear?”
Joshua Hackett, M.D.
Circadian-aligned. Mitochondrially-driven. Built for nature—not algorithms.
It's time to join the rebellion.
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